Apparently antidepressants can cause problems in sperm production. Thus, the quantity of sperm produced will be lower. Low sperm count is the number one male infertility problem today. well.does it?. Yahoo Answers Sign in Mail ⚙ Help Sperm count decreased has been reported by people with depression, enlarged prostate, psoriasis, attention deficit hyperactivity disorder, crohn's disease (latest reports from 234 Sperm count decreased patients). Best Answer: Yes, it does lower sperm count. It has an effect on the sperm's ability to swim, and their concentration. But talk to his doctor before abandoning his use of the drugs over concerns for his sperm count, as sudden changes in treatment may worsen psychiatric conditions. Prozac (generic name: fluoxetine) is is an SSRI (selective serotonin reuptake inhibitor) antidepressant that increases serotonin in the brain. The good news is that low sperm count does not necessarily prevent pregnancy from occurring and there is a lot you can do to improve your chances of getting pregnant. Click here to read couples’ success stories of conceiving with low sperm count. In addition, the extent of DNA fragmentation may be associated with lower fertility and worse pregnancy outcomes, even when using in vitro fertilization and intracytoplasmic sperm injection. Reassuringly, the authors did not find any statistically differences in the hormonal parameters assessed, including levels of follicle stimulating hormone, luteinizing hormone, or prolactin. There was also a decrease in sperm count and sperm motility in the fluoxetine groups compared with control mice. 10 Similarly, a study of citalopram in mice found that there was an increase in DNA strand breaks and oxidative DNA damage in sperm. 11 Neither of these studies specifically evaluated reproductive outcomes. Looking for medication to treat low sperm count? Find a list of current medications, their possible side effects, dosage, and efficacy when used to treat or reduce the symptoms of low sperm count Fluoxetine sperm count Does fluoxetine affect my sperm All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice.